Views: 450 Author: Site Editor Publish Time: 2025-03-01 Origin: Site
The compound 5-chloro-2-methyl-4-isothiazolin-3-one is a widely recognized biocide and preservative used across various industries. Its CAS：96118-96-6 designation allows for precise identification in chemical nomenclature and regulatory frameworks. Understanding the common name and applications of this compound is essential for professionals in fields such as water treatment, cosmetics, and industrial manufacturing.
The chemical structure of 5-chloro-2-methyl-4-isothiazolin-3-one consists of an isothiazolinone ring substituted with a chlorine atom at the fifth position and a methyl group at the second position. This molecular arrangement contributes to its potent biocidal activity. The compound is a member of the isothiazolinone family, known for their effectiveness in controlling microbial growth.
Physically, it appears as a colorless to pale yellow liquid with a mild odor. It is soluble in water and demonstrates stability under a range of temperatures and pH levels. These properties make it suitable for incorporation into various formulations where microbial inhibition is required.
The common name for 5-chloro-2-methyl-4-isothiazolin-3-one is Methylchloroisothiazolinone (MCI). This nomenclature is derived from the molecular structure, emphasizing the methyl and chloro substituents on the isothiazolinone ring. MCI is often used in combination with Methylisothiazolinone (MIT) to broaden the spectrum of antimicrobial activity.
MCI is recognized globally in various regulatory listings and safety data sheets under this common name. Its effectiveness as a preservative has led to widespread use in products requiring protection against bacterial and fungal contamination.
The synthesis of MCI involves the cyclization of precursors such as methylthiocyanate and chloramine. The process requires precise control of reaction conditions to ensure the purity and efficacy of the final product. Advances in chemical engineering have optimized production methods, reducing impurities and enhancing yield.
Industrial production facilities prioritize quality control measures, adhering to standards that meet regulatory requirements. This ensures that MCI produced is of high quality, suitable for use in sensitive applications like cosmetics and personal care products.
Key manufacturing hubs for MCI include regions with advanced chemical industries such as China, the United States, and parts of Europe. Companies in these areas benefit from established supply chains and technological infrastructure. For example, suppliers like CAS：96118-96-6 manufacturers adhere to strict environmental and safety protocols during production.
Methylchloroisothiazolinone is utilized primarily as a preservative due to its efficacy against a wide range of microorganisms. Its applications span multiple industries:
In water treatment processes, MCI is used to control slime-forming bacteria and algae in industrial recirculating cooling water systems. Its ability to remain active over varying pH levels makes it an effective biocide. The addition of MCI helps in reducing biofilm formation, which can impair system efficiency and lead to corrosion.
MCI is widely incorporated in cosmetics such as shampoos, lotions, and creams to prevent bacterial and fungal growth, extending product shelf life. Its use at low concentrations is effective, minimizing the risk of microbial contamination while maintaining product integrity. Regulatory bodies have set maximum allowable concentrations in consumer products to ensure safety.
In the paints and coatings industry, MCI acts as an in-can preservative, preventing microbial spoilage that can affect product quality. Its effectiveness in inhibiting bacteria and fungi helps maintain the desired properties of paints during storage. This reduces economic losses due to product degradation.
MCI is used in the paper industry to control microbial growth in pulp, paper mill water systems, and finished paper products. Microbial contamination can cause slime formation, leading to operational issues and reduced product quality. The application of MCI ensures smooth processing and high-quality paper output.
While MCI is effective as a biocide, its use raises safety and toxicity concerns, particularly regarding skin sensitization. Exposure to MCI can lead to allergic reactions in susceptible individuals. Studies have indicated a rise in contact dermatitis cases associated with MCI, leading to stricter regulations on its use in consumer products.
Occupational exposure during manufacturing and handling requires appropriate safety measures. Personal protective equipment (PPE) and adherence to safety protocols mitigate risks to workers. Material Safety Data Sheets (MSDS) provide guidelines on safe handling and emergency procedures.
Regulatory agencies worldwide have reviewed the safety data of MCI, resulting in restrictions on its allowable concentrations in various products. In the European Union, for instance, the use of MCI in leave-on cosmetic products has been banned, and its concentration in rinse-off products is limited to 0.0015% when in combination with MIT.
The United States Environmental Protection Agency (EPA) regulates MCI under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), requiring proper labeling and usage instructions. Manufacturers must comply with these regulations to legally distribute products containing MCI.
Due to safety concerns, there is a growing interest in finding alternative preservatives that offer similar efficacy with reduced health risks. Research is ongoing into natural and synthetic compounds that can replace MCI in formulations. Innovations in product packaging and formulation technologies also aim to reduce the reliance on preservatives.
Manufacturers are encouraged to stay informed about regulatory changes and advancements in preservative technology. Engaging with suppliers who provide up-to-date information and compliant products is essential. Companies like those offering CAS：96118-96-6 compounds can be valuable partners in navigating this evolving landscape.
The environmental impact of MCI is an area of concern, particularly its toxicity to aquatic organisms. When released into wastewater, it can affect microbial communities important for wastewater treatment processes. Biodegradation studies show that MCI can persist in the environment under certain conditions.
Efforts to mitigate environmental risks include improving waste management practices and exploring treatment methods to degrade MCI in effluents. Advanced oxidation processes and biodegradation using specific bacterial strains are areas of active research.
Proper handling and storage of MCI are crucial to maintain safety and product integrity. Containers should be tightly closed and stored in a cool, well-ventilated area away from incompatible materials such as strong oxidizing agents. Employee training on safe handling procedures reduces the risk of accidental exposure and spills.
In case of a spill or accidental release, immediate measures should be taken to contain and clean up the material using appropriate protective equipment. Disposal must comply with local environmental regulations to prevent environmental contamination.
Accurate detection and quantification of MCI in products and environmental samples are essential for compliance and safety assessments. Common analytical methods include High-Performance Liquid Chromatography (HPLC) coupled with UV detection or Mass Spectrometry (MS). These techniques offer sensitivity and specificity necessary for low-concentration measurements.
Regular monitoring ensures that MCI levels remain within regulatory limits and helps in identifying potential sources of contamination. Analytical laboratories specializing in such measurements provide services to manufacturers and regulators alike.
Methylchloroisothiazolinone (MCI), known chemically as 5-chloro-2-methyl-4-isothiazolin-3-one, plays a significant role as a preservative and biocide in various industries. Its effectiveness against a broad spectrum of microorganisms makes it valuable, yet safety and environmental concerns necessitate careful management. By adhering to regulatory guidelines and exploring alternatives, industries can balance the benefits of MCI with the imperative of safety. For suppliers and manufacturers dealing with CAS：96118-96-6, ongoing vigilance and commitment to best practices are essential for sustainable operations.
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